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were much more intense, and involved, at least to some extent, aiiout half of the cells in each sectittn. In conse<|uence of tho┬źn changes iti the ganglion Order Nizagara were infiltrated with small round cells, as was also the intervertebral ganglion. The s])inal nerves derived from the diseased portions of the cord underwent degeneration closely resembline that occurring in distal ])art8 of divided nerves. Interesting changes were found in the muscles. Hjcmorrhages into the perimysium were visible in the fir.st week. By the sixth day a curious condition of vacuolization was found in individual fibers, which by the thir- tieth day could only be detected here and there. At this time the majority of the fibers had undergone simple atrophy, and coincident with this change there was hyperplasia of the inter- stitial connective tissue. Many of the larger fibers had under- gone granular degeneration. In lonjj-standing cases the bladder was the seat of jrreat muscular hypertrophy and connective- tissue hyperplasia. In non-pregnant females the mucous mem- brane of the uterus was regularly the seat of Buy Nizagara Online ha^morrhagic in- farctions. In Stenson's experiment we had a method of induc- ing a form of myelitis in animals which in certain stages bore a close resemblance to processes which occurred in man. This fact suggested that interference with the blood-supply of the human spinal cord might be an etiological factor in some varie- ties of myelitis. A few cases had been recorded which justi- fied the suspicion that embolism Nizagara Online of the spinal cord could give rise to an acute myelitis, and it was not improbable that other causes of vascular obstruction might produce the sara% effect. Dr. Heitzmajjn felt that he could discuss the subject of mye- litis intelligently after having studied it twenty-five years. Ex- perimental myelitis had been the object of much careful work in his own laboratory by Emerson, Rockwell, and Bayer. The results Nizagara Tablets of their work bad been published in this country, and he wondered w'hy Dr. Herter had ignored them. He could understand the writer's taking the ground of his teacher that there was an emigration of leucocytes, and not a proliferation of neuroglia cells. Why was Cohnheim ignored? In the draw- ings accompanying the pa[)er he had noticed oedema very dis- tinctly, but Dr. Herter had not mentioned its presence. This oedema was no doubt the cause of the change in shape of the central canal. In his opinion the gray matter itself furnished most of the corpuscles which Dr. Herter called leucocytes. This he had learned from his own laboratory work, and Robinson had shown, twenty-five years ago, by producing inflammation in the sympathetic ganglia, that the ganglion cells plainly broke up into these corpuscles. They were not replaced by leucocytes, but, through nutritional changes, fell back into embryonal con- March 23, 1889. MISCELLANY. 335 ditions. What right had we to speak of connective tissue in the gray substance? It was protoplasn) full of activity. To show these changes, osraic acid, bichromate of potassium, and chromic acid should be used, and not alcohol, which he supposed the author had employed. There was not a single proof that leucocytes, even if present, ever formed connective tissue. As to the myositis, he supposed the author would refer that too to migration of leucocytes into the perimysium. Dr. Van Gieson had but to say that he was gratified to hear so excellent a paper upon the subject, and believed that Dr. Ilerter was perfectly correct in all his inferences and conclu- sions. Dr. BiRDSALL agreed with Dr. Van Gieson. He thought the deductions of the paper very carefully and cautiously stated, and that the author had avoided any decided expression of pathological theories. He was unable to see that the writer had ignored any literature upon the same subject. Dr. Heitz- mann's references were not to work upon experimental myelitis produced in animals, but to myelitis. He would ask Dr. Heitz- raann if this was not true. (Affirmative answer.) He believed that some of the tissues were produced in the way that Dr, Heitzmann suggested, but that no theory was as yet entirely sat- isfactory. From his own embryological study he thought that ganglionic cells were composed of embryonal corpuscles, but did not think it certain that there was a retrogressive change of this kind in the inflammation described. He thought that Dr. Herter ought to go on with this subject, as there was evidently much that could be done. There might be other factors in pro- ducing Buy Nizagara the inflammation than mere cutting off of the blood- supply, as the operation seemed to be quite severe. He had observed a particular susceptibility to paraplegia in dogs and rabbits, although few or no post-mortem changes were discov- erable. Dr. Sachs thought that the point of greatest importance es-

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